Effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline.
نویسندگان
چکیده
In a single dose crossover study, the effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline was investigated. Compared to fasting subjects, carbohydrate and fat rich diet caused an enhancement of absorption half life and a lower Cmax with a delayed tmax and elimination of the bronchodilator. Protein coadministration decreased AUCO-OC of the drug without significantly altering its absorption or elimination kinetics.
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عنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 37 4 شماره
صفحات -
تاریخ انتشار 1993